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The most potent source of Vitamin D is the sun. Although to be more accurate, it is the action of the sun’s energy on melanin in human skin actually produces the Vitamin D. Given the easy access to sunlight, it would seem that of all vitamins, this is one that we would never need to introduce in supplement form into our diets. And yet, this is not necessarily the case.

Like calcium, Vitamin D is necessary for strong teeth and bones. Since fewer Americans are drinking Vitamin D-fortified, many Americans are experiencing a deficiency. Vitamin D is obtained through foods as well and through exposure to sunlight. Because of the concern of skin cancer, many have decreased their exposure to the sun.

A deficiency in Vitamin D is a significant problem for post-menopausal women. Because calcium supplementation cannot reverse osteoporosis alone, Vitamin D is required to boost its absorption rate. Together, they may reverse or prevent osteoporosis if taken regularly before menopause.

Low levels of Vitamin D may result in high blood pressure and may also cause calcium buildup in the arteries, which may result in a heart attack or stroke. Vitamin D deficiency has also been associated with obesity.

Vitamin D is a fat-soluble vitamin that is naturally present in very few foods, added to others, and available as a dietary supplement. It is also produced endogenously when ultraviolet rays from sunlight strike the skin and trigger Vitamin D synthesis. Vitamin D obtained from sun exposure, food, and supplements is biologically inert and must undergo two hydroxylations in the body for activation. The first occurs in the liver and converts Vitamin D to 25-hydroxyvitamin D, also known as calcidiol. The second occurs primarily in the kidney and forms the physiologically active 1,25-dihydroxyvitamin D, also known as calcitriol.

Vitamin D is essential for promoting calcium absorption in the gut and maintaining adequate serum calcium and phosphate concentrations to enable normal mineralization of bone and prevent hypocalcemic tetany. Without sufficient Vitamin D, bones can become thin, brittle, or misshapen. Vitamin D sufficiency prevents rickets in children and osteomalacia in adults Calcium and vitamin D also helps protect older adults from osteoporosis.

Vitamin D has other roles in human health, including modulation of neuromuscular and immune function and reduction of inflammation. Many genes encoding proteins that regulate cell proliferation, differentiation, and apoptosis are modulated in part by Vitamin D.

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